3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE - Names and Identifiers
Name | flavoxate hydrochloride
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Synonyms | Urispas DW-61
bladderon genurin
spasuret
bladderon
REC-7-0040
nsc-114649
FLAVOXATE HCL
FLAVOMYCINPREMIX flavoxate hydrochloride flaroxatehydrochloride
Flavoxate Hydrochloride (200 mg) piperidinoethyl-3-methylflavone-8-carboxylatehydrochloride
3-methyl-4-oxo-2-phenyl-4h-1-benzopyran-8-carboxylicaci2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4h-1-benzopyran-8-carboxylicaci2-piperidinoethyl
1-piperidineethanol,3-methyl-4-oxo-2-phenyl-4h-1-benzopyran-8-carboxylate,h 2-piperidinoethyl-3-methyl-4-oxo-2-phenyl-4h-1-benzopyran-8-carboxylatehydro 1-piperidineethanol,3-methyl-4-oxo-2-phenyl-4h-1-benzopyran-8-carboxylate,h
2-piperidinoethyl-3-methyl-4-oxo-2-phenyl-4h-1-benzopyran-8-carboxylatehydro
3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE 3-METHYL-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-8-CARBOXYLIC ACID 2-(1-PIPERIDINYL)ETHYL ESTER HYDROCHLORIDE
Flavoxate hydrochloride,3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester hydrochloride, DW-61, Rec-7-0040
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CAS | 3717-88-2
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EINECS | 223-066-4 |
InChI | InChI=1/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H |
3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE - Physico-chemical Properties
Molecular Formula | C24H26ClNO4
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Molar Mass | 427.92 |
Melting Point | 232-234°C |
Boling Point | 564.1°C at 760 mmHg |
Flash Point | 294.9°C |
Solubility | H2O: ~6.6mg/mL |
Vapor Presure | 9.56E-13mmHg at 25°C |
Appearance | solid |
Color | white |
Storage Condition | Inert atmosphere,Room Temperature |
Physical and Chemical Properties | This product is white crystalline powder; Odorless, bitter taste. This product is dissolved in chloroform, slightly soluble in water or methanol, almost insoluble in acetone or ether, dissolved in glacial acetic acid.
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Use | Urinary System medication |
In vitro study | Flavoxate at Ca Flavoxate (> amp; Gt; 10 μm) inhibited acetylcholine-induced contraction of isolated rat detrusor muscle with a pD value of 4.55. Flavoxate (> amp; Gt; 10 μm) inhibits Ca Flavoxate (0.01 μm − 10 μm) concentration-dependently inhibits CAMP formation in membranes extracted from rat striatum and cerebral cortex, pretreatment with pertussis toxin (PTX) completely abolished the effect. Flavoxate concentration-dependent reduction of K |
In vivo study | In rats, Flavoxate (10 mg/kg) inhibited both initial, rapidly ascending phase systolic (phase 1) and tonic systolic (phase 2) contractions to the same extent. In rats, Flavoxate (10 mg/kg) abolished bladder contractile function without causing any change in the amplitude of contraction. Flavoxate (3 mg/kg) halted efferent nerve activity and associated bladder contractile function for about 10 min without altering the basal bladder pressure in rats. In rats, ICV injection (50 to 200 μg/rat) or IT Injection (100 to 200 μg/rat) Flavoxate, during or after 5 to 15 minutes of injection, it dose-dependently abolishes rhythmic bladder contractions. Flavoxate (3 mg/kg, I. V.) abolished rhythmic bladder contractions and the maximal interval of micturition contractions was 7.20 min. |
3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE - Risk and Safety
Hazard Symbols | Xn - Harmful
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Risk Codes | R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
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WGK Germany | 3 |
RTECS | DJ2450000 |
HS Code | 29349990 |
Toxicity | LD50 i.v. in rats: 27.4 mg/kg (Cazzulani) |
3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE - Standard
Authoritative Data Verified Data
This product is 3-methyl-2-phenyl-4-oxo-4h-1-benzopyran-8-carboxylic acid-2-piperidine ethyl ester hydrochloride. The content of C24H25N04 • HC1 shall not be less than 99.0% calculated on a dry basis.
Last Update:2024-01-02 23:10:35
3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless.
- This product is dissolved in chloroform, slightly soluble in water or methanol, and almost insoluble in acetone or ether; It is dissolved in ice fermented liquid acid.
absorption coefficient
take this product, precision weighing, plus O.Olmol / L hydrochloric acid solution is dissolved and quantitatively diluted to prepare a solution containing about 20ug per 1 ml, and the absorbance is measured at the wavelength of 293nm by UV-Vis spectrophotometry (General rule 0401), the absorption coefficient is 300 to 330.
Last Update:2022-01-01 15:33:41
3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE - Differential diagnosis
Authoritative Data Verified Data
- take about 10mg of this product, add methanol 3ml to dissolve, add hydrochloric acid 0.5ml, add magnesium powder 50mg, shake, place for 10 minutes, appear orange yellow.
- take this product, add O.lmol/L hydrochloric acid solution was dissolved and diluted to prepare a solution containing about 20ug per lml, which was determined by UV-Vis spectrophotometry (General rule 0401) at 241nm, there is a maximum absorption at the wavelength of 293nm and 318nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1031).
- the product of aqueous solution (1-100) chloride identification (1) of the reaction (General 0301).
Last Update:2022-01-01 15:33:41
3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE - Exam
Authoritative Data Verified Data
clarity of the solution
take 0.lg of this product, heat 20ml of water, shake and dissolve, let cool, and the solution should be clarified.
Related substances
take this product, add the solvent [chloroform-methanol (1:1)] Dissolved and diluted into each 1 ml containing 20mg of solution, as a test solution; precision take the right amount, plus the above solvent quantitative dilution made per lml containing 0.lmg solution, as a control solution; Another 3-methyl flavone -8-acid (impurity I) control, precision weighing, the above solvent was added to dissolve and quantitatively diluted to prepare a solution containing 0.10 mg solution, as a control solution. According to the thin layer chromatography (General 0502) test, absorb the above three solutions of 10 u1, respectively, on the same silica gel GF254 thin layer plate, with cyclohexane-ethyl acetate-methanol-diethylamine (8:2:2:1) for the development of the solvent, expand, dry, set the UV lamp (254mn) under the inspection, the test solution such as impurity spots, not more than 2, the color of the impurity spot in the same position as the control solution shall not be deeper than that of the main spot of the control solution, and the color of the other impurity spot shall be compared with that of the main spot of the control solution, not deeper.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
arsenic salt
take 2.0g of this product, put it in a porcelain crucible, and add magnesium nitrate l.Og, ethanol 10ml, ignition, slowly burn to carbonization, then wet with a small amount of nitric acid, Heat burn and burn at 500°C to ash, cool, add hydrochloric acid 3ml, dissolve the residue by heating on a water bath, transfer the residue to an arsenic bottle with 23ml of water, add 2ml of hydrochloric acid as a test solution; Take another 2ml of standard arsenic solution and place it in a crucible, from the "addition of magnesium nitrate 1.0g", the same method as the test solution shall be operated and inspected according to law (General Principles 0822, first law), and the provisions (0.0001%) shall be met.
Last Update:2022-01-01 15:33:42
3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE - Content determination
Authoritative Data Verified Data
take this product about G, precision weighing, add glacial acetic acid 5ml and acetonitrile 20ml dissolved, add acetic anhydride 25ml, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the titration results were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/ L) corresponds to 42.79mg of C24H25NO4. HCl.
Last Update:2022-01-01 15:33:43
3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE - Category
Authoritative Data Verified Data
Last Update:2022-01-01 15:33:43
3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update:2022-01-01 15:33:43
3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE - Flavoxate Hydrochloride Tablets
Authoritative Data Verified Data
This product contains flavanone hydrochloride (C24H25NO4 • HCl) should be 90.0% ~ 110.0% of the label amount.
trait
This product is sugar-coated tablet or film-coated tablet, White after removing the coating.
identification
- take an appropriate amount of fine powder of this product (about 0.1g of flavanone hydrochloride), add 10ml of methanol, shake, place it in a 60°C water bath and heat it for 5 minutes to dissolve flavanone hydrochloride and let it cool, filter, take the filtrate, add hydrochloric acid 0.5, add magnesium powder about 50mg, shake, place for 10 minutes, the solution appears orange yellow.
- the solution under the content measurement was measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at wavelengths of NM, NM and 318nm.
examination
- Related substances take appropriate amount of fine powder of this product and add solvent [chloroform-methanol (1:1)] shake to dissolve and dilute the flavanone hydrochloride into a solution containing 20mg flavanone hydrochloride per 1 ml, filter, and use the filtrate as the sample solution, quantitative dilution with the above solvent to make each 1 ml containing hydrochloric acid flavone 0. A 1 mg solution was used as a control solution; A control product of impurity I was additionally taken, dissolved with the above solvent and quantitatively diluted to give a solution containing 0.20mg per 1 ml as a control solution. The test was carried out according to the method in the related substances of flavoxate hydrochloride. The test solution should not have more than 2 impurity spots, and the color of the spots in the same position of the control solution should not be deeper than the main spot of the control solution, the color of the other impurity spot should not be deeper than the main spot of the control solution.
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 first method), with water as the dissolution medium, the speed is 100 rpm, according to the law, after 30 minutes, take the appropriate amount of solution filtration, precision take the appropriate amount of filtrate, with 0.1 mol / L hydrochloric acid solution was quantitatively diluted to prepare a solution containing about 20% flavone hydrochloride in 1 ml. According to the method under the content determination item, calculate the dissolution of each tablet, the limit is 70% of the labeled amount, should comply with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, remove the coating, precision weighing, fine grinding, precision weighing an appropriate amount (about 0.2g equivalent to flavanone hydrochloride), put it in a 100 measuring flask, add 0. Appropriate amount of lmol/ L hydrochloric acid solution, heated in a water bath at 60°C for 20 minutes, and continuously shaken to dissolve flavanone hydrochloride, let it cool, and add 0.lmol/ L hydrochloric acid solution to dilute to the scale, shake, filter, take the appropriate amount of filtrate, with 0.1 mol/L hydrochloric acid solution was quantitatively diluted to make a solution containing 20ug of flavone hydrochloride in 1 ml, and the absorbance was measured at the wavelength of 293mn by ultraviolet-visible spectrophotometry (General rule 0401); in addition, take the flavone Ester hydrochloride control, precision weighing, plus 0.lmol/ L hydrochloric acid solution is dissolved and quantitatively diluted to make a solution containing 20ug per lml, which is determined and calculated by the same method.
category
The same as flavanone hydrochloride.
specification
(1)0.lg (2)0.2g
storability
light shielding, sealed storage.
Last Update:2022-01-01 15:33:44
3-METHYL-4-OXO-2-PHENYL-4H-BENZOPYRAN-8-CARBOXYLIC ACID 2-PIPERIDINYL ETHYL ESTER HYDROCHLORIDE - Flavoxate hydrochloride capsules
Authoritative Data Verified Data
This product contains flavoxate hydrochloride (C24H25N04 • HCl) should be 90.0% ~ 110.0% of label amount
trait
The content of this product is white or white powder.
identification
- take an appropriate amount of the content of this product (about 0.1g of flavanone hydrochloride), add 10ml of methanol, shake, and heat it on a 60°C water bath for 5 minutes to dissolve flavanone hydrochloride, cool, filter, take the filtrate, add 0.5M l of hydrochloric acid, add about 50mg of magnesium powder, shake, place for 10 minutes, the solution appears orange yellow.
- the sample solution under the content measurement item was taken and measured by ultraviolet-visible spectrophotometry (General rule 0401), and the maximum absorption was found at wavelengths of 241nm, 293nm and 318nm.
examination
- Related substances take the contents of this product, add solvent [three gas methane-methanol (1:1 )] shake to dissolve and dilute the flavanone hydrochloride into a solution containing 20mg flavanone hydrochloride per 1 ml, filter, and use the filtrate as the sample solution, quantitative dilution with the above solvent to make each 1 ml containing hydrochloric acid flavone 0. A 1 mg solution was used as a control solution; A control product of impurity I was additionally taken, dissolved with the above solvent and quantitatively diluted to give a solution containing 0.20mg per 1 ml as a control solution. The test was carried out according to the method in the related substances of flavoxate hydrochloride. The test solution should not have more than 2 impurity spots, and the color of the spots in the same position of the control solution should not be deeper than the main spot of the control solution, the color of the other impurity spot should not be deeper than that of the main spot of the control solution.
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 first method), with water as the dissolution medium, the speed is 100 rpm, according to the law, after 30 minutes, take the appropriate amount of solution filtration, precision take the appropriate amount of filtrate, with 0. The lmol / L hydrochloric acid solution is quantitatively diluted to make a solution containing about 20ug of flavanone hydrochloride per lml, which is determined according to the method under the content determination item, and the dissolution amount of each particle is calculated, the limit is 80% of the labeled amount and shall be in accordance with the provisions.
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
take the contents under the item of difference in loading, grind them finely, weigh an appropriate amount (about 0.2g equivalent to flavanone hydrochloride), put it in a 100ml measuring flask, and add 0.1 mol / L hydrochloric acid solution appropriate amount, 60 ° C. Water bath heating for 20 minutes, and constantly shake to dissolve flavone hydrochloride, cool, add 0. Dilute lmol / L hydrochloric acid solution to the scale, shake, filter, take appropriate amount of filtrate with precision, dilute quantitatively with 0.lmol / L hydrochloric acid solution to prepare a solution containing 20ug of flavanone hydrochloride per 1 ml, as the test solution, according to ultraviolet-visible spectrophotometry (General rule 0401), determine the absorbance at the wavelength of 293nm; Take the flavone hydrochloride Ester control, precision weighing, add 0.lmol / L hydrochloric acid solution dissolved and quantitatively diluted to make a solution containing 20ug per lml, the same method of determination, calculation, that is.
category
The same as flavanone hydrochloride.
specification
(1)0.lg (2)0.2g
storage
light shielding, sealed storage.
Last Update:2022-01-01 15:33:45